Case-Based Modules > Case 11 > Stage 2
Sorry! It's tempting to try this-- why wouldn't we want to empirically give something that could reduce bleeding? If we got a TEG or ROTEM and it was strongly suggestive of hyperfibrinolysis, then sure, we could do that. We shouldn't be doing this empirically, however.
The largest RCT on this subject looked at short-term therapy with TXA versus placebo up to the point of aneurysm securing, up to 24 hours. There was no statistically significant difference in rebleeding events and no improvement in functional outcomes at 6 months.
A subsequent meta-analysis found no improvement in mortality or functional outcome. Thus, the 2023 AHA/ASA guidelines recommend against the routine usage of TXA for aSAH.
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Suggested Reading:
- Post R, Germans MR, Tjerkstra MA, et al. Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial. Lancet. 2021;397(10269):112-118. doi:10.1016/S0140-6736(20)32518-6
- Shi M, Yang C, Chen ZH, Xiao LF, Zhao WY. Efficacy and Safety of Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Surg. 2022;8:790149. Published 2022 Jan 10. doi:10.3389/fsurg.2021.790149
- Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association [published correction appears in Stroke. 2023 Dec;54(12):e516. doi: 10.1161/STR.0000000000000449.]. Stroke. 2023;54(7):e314-e370. doi:10.1161/STR.0000000000000436